Waters
Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry
Transform your quantitative capabilities. Accessible reliable performance. High performance quantitation, accessible to all. Routine testing doesn’t have to be limited – maximize your performance by expanding your analytes per injection and extending your validated concentration range, without increasing your lab footprint. Delivering purpose driven performance, so you can: ▪ easily acquire and review your quantitative data to meet your analytical and regulatory needs ▪ target more analytes per injection and cover a wider concentration range ▪ develop robust methods and easily set up your system for analysis Reliable performance so you can meet your analytical and regulatory requirements Save time on reporting results by using technologies that can meet requirements first time and every time. The Xevo TQ-S cronos is extremely robust and includes new reversed geometry sample cone that maximizes uptime, using technology developed from our award-winning QDa mass detector Save time on method development and quantitative data review It’s easy to transfer methods onto the Xevo TQ-S cronos using QUANPEDIA software, which enables databases of compounds to be stored with the appropriate methods. Discover new updates to our quantitation software. ▪ New flags in TargetLynx summary bar make it easy to see any out-of-tolerance samples ▪ Link your acquisition to processing methods to automatically update MRM function numbers ▪ Automatically update QUANPEDIA retention times from processed TargetLynx data files More analytes per injection across a wider concentration range Quantify more compounds with each chromatographic run using ultra fast MRM acquisition rates of 555 MRM/s. Maximize laboratory efficiency by reducing the need to dilute and reinject in cases where components are present at extremely high concentrations with five orders of linear dynamic range. ▪ Data quality at speed – peak intensity from an acquisition rate of 555 MRM/s is no more than 25% less than the peak intensity from an acquisition rate of 50 MRM/s ▪ Wide linear dynamic range – quantifying samples with unknown analyte concentrations can be time consuming Multi-residue pesticide testing performance you can rely on An example of an application area that the Xevo TQ-S cronos excels in is multi-residue pesticide testing. Not only will the Xevo TQ-S cronos deliver accurate, precise results but it will also work day in, day out with minimal user intervention. ▪ 204 LC-amenable pesticides tested in cucumber, tomato and capsicum matrices ▪ Straightforward DisQuE (CEN) with PSA dSPE sample preparation ▪ 1 in 10 dilution of extracts for excellent long term performance ▪ Superior linearity and consistency of ion ratios to meet analytical and regulatory requirements
Waters
Xevo TQ-S micro Triple Quadrupole Mass Spectrometry
High Performance from a Compact Design with Rapid, Reliable and Reproducible Quantitative Data Revolutionary design has produced a tandem quadrupole instrument with a small footprint that delivers consistent low levels of quantitation with a wide dynamic range. ▪ Class-leading performance that can fit into any lab ▪ Quantify highly polar, ionic compounds in food ▪ Benefit from flexibility and compatibility across the board ▪ Robust performance, even with the most complex sample matrices Features and Benefits Class-leading performance that can fit into any lab From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S micro provides superior performance per square inch and exceptional analytical flexibility. The Xevo TQ-S micro is able to reproduce high quality analytical performance injection after injection, even with the most complex sample matrices. Reliable instrument operation maximizes laboratory efficiency, delivering outstanding sensitivity for such a compact instrument. Quantify highly polar, ionic compounds in food The Xevo TQ-S micro’s reliable quantitative performance is shown in this example for glyphosate in cucumber. Excellent quantitative performance over a suitable calibration range is achieved for matrix matched calibration curves overlaid, which have bracketed an analytical run of over 40 injections. All back calculated concentrations are well within the 20% deviation permitted by SANTE/11813/2017. Highlighted from the curve is an example of the excellent performance achieved for glyphosate in cucumber, relative to the original Xevo TQ-S micro, illustrating suitability for checking compliance with MRLs set around the globe and for use for due diligence by the food industry. Flexibility and compatibility across the board Achieve more with increased flexibility delivered through a wider range of source and inlet options. Coverage for every application area is guaranteed through compatibility with Waters Universal Ion Source Architecture including: ▪ ESI, APCI, ESCi ▪ UniSpray ▪ APGC ▪ ionKey/MS ▪ ASAP ▪ Nanoflow ESI Chromatographic versatility is guaranteed through compatibility with: ▪ ACQUITY UPLC H-Class PLUS, H-Class Bio PLUS, H-Class Binary PLUS ▪ ACQUITY UPLC I-Class PLUS ▪ ACQUITY UPC2 ▪ ACQUITY M-Class ▪ GC Inherent robustness Robust performance begins in the source with Z-Spray geometry, efficiently removing neutral molecules while drawing ions through the sample cone into the analyzer. The StepWave ion guide in the Xevo TQ-S micro is designed to cope with the challenges in the modern laboratory that are produced by high sample throughput and difficult matrices. Neutrals and gas load are passively removed for enhanced transmission with the ions actively transferred into the mass analyzer, improving sensitivity and robustness.
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Waters
Xevo TQ-XS Triple Quadrupole Mass Spectrometry
One system. Every analyte. All the time. Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo® TQ-XS offers: ▪ StepWave XSTM ion guide that provides increased sensitivity for challenging compounds. ▪ Enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible. ▪ Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users. Features and Benefits Reproducible, ultimate sensitivity quantitation Whether you are analyzing small or large molecules, single analytes or multiple panels of compounds, the Xevo TQ-XS will give you the results you need, first time and without complication. The new StepWave XS ion guide provides improved sensitivity that is reproducible for multiple injections and can provide reliable quantitation at the very lowest levels. StepWave XS ensures neutrals and gas load are passively removed for enhanced transmission, with the ions actively transferred into the mass analyser, improving sensitivity and robustness. The first stage is modified with a series of horizontal plates that allows a more controlled extraction of ions from the gas flow so that ions collide with gas molecules with less energy. A segmented quadrupole second stage focuses the ion beam to provide more efficient transmission of ions from the source to the detector. Pushing the boundaries – leading technology The key technologies that enable you to do more with your instrument start with UniSprayTM which ionizes a wider range of compounds than any other single technique. Combining wider compound coverage with an extremely easy to use source, UniSpray can deliver results to your laboratory for more compounds than before, without having to change source or probe. So you can spend more time delivering results and less time changing instrument parts. Robust results you can trust with the most demanding sample matrices The routine challenges of complex matrices are overcome by the Xevo TQ-XS which provides reproducible results injection after injection despite difficult sample matrices. In a study involving 2,000 injections of protein-precipitated plasma and analyzing sulphadimethoxine, there was little variation in peak area over the entire injection series with <3% RSD. This study aimed to reproduce the challenging conditions found in many analytical laboratories by also using a short dwell time of only 5 ms.
Waters
LC Prep 150 System
A versatile system to suit your purification requirements The LC Prep 150 System is the perfect fit-for-purpose solution for the rapid isolation and collection of your valuable complex samples with complete confidence. ▪ Purification – made simple ▪ Robust system performance with intuitive ChromScope Software ▪ Confidently scale methods from analytical to prep ▪ Rapidly process your complex mixtures with complete confidence Features ▪ Flexible solvent delivery options allowing binary or quaternary based pumps providing low-pressure multi-solvent blending or high pressure gradient mixing of flow rates up to 150 ml/min. ▪ Easy to use manual or automated sample injection options allow the versatility to accommodate a wide range of workload requirements. ▪ Identify and isolate your compounds of interest with the highly sensitive 2489 UV/Visible or 2998 Photodiode Array detectors, providing enhanced linear range to accommodate highly concentrated samples. ▪ Confidently purify sample loads of milligrams to grams when using internal column diameters of up to 50mm. ▪ Use the easy-to-navigate ChromScope software delivered with sample set wizard, stacked injection wizard, key fraction collection parameters, fraction simulation modeling, and customizable reporting with drop and drag features.
Waters
LC Prep AutoPurification System
Preparative-scale chromatography plays a critical role in applications where compounds must be synthesized, identified, isolated, purified, characterized, screened, and tested. Waters AutoPurification Systems offer scalable prep configurations, whether you want the specificity of mass-directed purification or inclusiveness of a UV system. The LC Prep AutoPurification System provides you with the flexibility of using high-throughput parallel runs for selective mass-directed fraction collection from hundreds of samples. With the LC Prep AutoPurification System, run samples around the clock with unprecedented versatility and consistency. ▪ Take the complexity out of purification with our versatile solutions that are capable of purifying micrograms to multigram quantities. ▪ Automatically process hundreds of samples – or just a few. ▪ Robust and reliable systems improve your ability to manage increasing workload demands, including unattended instrument operation. ▪ Flexible configurations enable easy scale-up from analytical to preparative chromatography. ▪ FractionLynx Application Manager automates the collection of detected fractions, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including UV/Visible, Evaporative Light Scattering (ELS), MS, and analog. ▪ User-friendly console and software features help you manage solvents and samples, whether you do manual or automated injections. ▪ Proprietary Optimum Bed Density (OBD) Column design offers the highest sample loading and unmatched column stability. ▪ Easy-to-upgrade systems help you bring the latest technologies to your lab.
Waters
SFC Prep 150 AP System
Designed for automated UV and/or MS-triggered purification The Prep 150 AP SFC System is the first and only commercially available preparative SFC system offering automated sample handling, column switching, fraction collection and tracking in an easy-to-use, open bed format. The Prep 150 AP SFC System provides routine compound purification for drug discovery labs using the MassLynx Software with FractionLynx Application Manager. This system offers fast separations, high resolution and high throughput. The inherent benefits of SFC, combined with Waters’ world renowned service and support provides users with a robust, cost effective solution to any purification lab. SFC Prep 150 AP System The SFC Prep 150 AP System automates the purification process by linking analytical pre- screen, purification and fraction re-analysis with AutoPurify in an “open access” setting. Stacked Injection capability is also available for the purification of large amounts of material delivering multiple injections and allowing for multiple peaks collected into separate vessels. Features ▪ QGM Low Pressure mixing Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150mL/min as serves as the co-solvent delivery device for this system. P200X CO2 Pump: This is a high pressure delivery pump having dual stainless steel heads with a cam driven sapphire piston assembly; self priming check valves; presser sensor; pressure gauge; brushless motor and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter. Modifier Stream Injector: This design supports customers requests of Modified Stream Injection ONLY. It’s function is to inject one sample at a time using a standard 2mL loop and a 5mL syringe. This device allows for settable air gaps on either side of the sample. The air gap functions as a buffer between the solvent and the sample decreasing dilution. 3767 Sample Manager: This module provides injection and collection capability in an open bed format. The system includes the fume hood assembly for the 3767 for CO2 management. Injection and collection racks must be ordered for the system. The specific racks required will be determined by your needs and requirements.
Waters
SFC Prep 150 Mgm System
A greener approach to high throughput purification Designed for high throughput, semi-prep to preparative scale purifications, the SFC Prep 150 Mgm System is made for repeat injection (bulk purification) of Chiral and Achiral compounds. It operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. It is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System has a maximum flow rate, CO2 and co-solvent combined, up to 150 mL/minute allowing use of 19 mm and 30 mm columns. It also has capacity for six fraction collection positions (two liters each). Controlled by the Waters Chromscope 2.1 SFC Software running under Windows 10, the user can take advantage of a new intuitive graphical interface. The SFC Prep 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. ChromScope v2.1 is an updated version of ChromScope Software that enables support of the Waters SFC Prep 150 Mgm System with the ACQUITY QDa Mass Detector. Additionally, this update adds support for ELSD and the ISM. The Waters SFC Prep 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly SFC systems utilize liquid carbon dioxide (CO2) as its main mobile phase in combination with one or more organic solvents resulting in faster equilibration, lower pressure drops across the column, solvent reduction and lower cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the Pharmaceutical, Life Sciences, Chemical Materials and Food & Environmental markets. System Features QGM Low Pressure mixing Quaternary Gradient Pump: This pump delivers flowrates up to a maximum of 150mL/min serves as the co-solvent delivery device for this system. P200X CO2 Pump: This is a high pressure delivery pump having dual stainless steel heads with a cam driven sapphire piston assembly; self priming check valves; presser sensor; pressure gauge; brushless motor and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter. Modifier Stream Injector: This design supports customers requests of Modified Stream Injection ONLY. It’s function is to inject one sample at a time using a standard 2-mL loop and a 5-mL syringe. This device allows for settable air gaps on either side of the sample. The air gap functions as a buffer between the solvent and the sample decreasing dilution. Prep Collection Cabinet: This collection cabinet comes with a retractable front door allowing for easy insertion and removal of 2-Liter Fraction Bottles. It has an exhaust port located in the upper backside of the cabinet to easily fit laboratories around the world requiring exhaust. It comes standard with a removable spill tray. Effortless Integration with the ACQUITY QDa Mass Detector: The intuitive design of the ACQUITY QDa Mass Detector gives you the additional data you need without the cost and complexity of traditional mass spectrometry. Now you can have access to the analytical confidence from the selectivity that mass detection brings to your analysis.
Waters
SFC Prep 350 System
Waters’ suite of bulk-scale supercritical fluid chromatography (SFC) purification systems offers the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample. When faster and more cost-effective means sustainable business operations, SFC is the purification technique that makes the difference. The preparative-scale SFC Prep 350 System is an automated system that features co-solvent gradient, high pressure separators for quantitative recovery of purified products, such as enantiomers, complex synthetic chemicals and natural products. The system is designed for chiral and achiral separations. Features ▪ High pressure CO2 pump ▪ High pressure co-solvent pump ▪ Injection module ▪ UV-Vis detector ▪ Fraction collection module ▪ Automated Back Pressure Regulator (ABPR) ▪ ChromScope Software
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